Negative regulation of autophagosome assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of autophagosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX11, PCNT, and PRC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of autophagosome assembly activity versus SOX11 in GBM (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOX11 →	-0.950	-0.346	.001	.006	3	4
LSCC	PCNT →	-0.317	-0.561	.002	<.001	3	4
LSCC	PRC1 →	-0.497	-0.917	<.001	<.001	3	4
LSCC	ASAH1 →	+0.427	+0.555	<.001	<.001	3	4
LSCC	DOCK8 →	+0.527	+0.556	<.001	<.001	3	4
LSCC	FAHD2A →	-0.379	-0.688	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902902 vs SOX11 — GBM

Explore this scatter interactively →