Negative regulation of autophagosome assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of autophagosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP2K, PHAX, and ATP13A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMP2K grouped by Negative regulation of autophagosome assembly-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BMP2K →	-0.979	-1.125	<.001	<.001	3	4
LARGE_INTESTINE	PHAX →	-0.508	-0.980	.006	.006	3	4
LUNG_NSCLC_LUSC	ATP13A1 →	+0.711	+1.054	.005	.004	3	4
KIDNEY	ZNF274 →	+1.522	+1.584	.002	<.001	3	4
KIDNEY	C18orf32 →	+0.799	+1.039	<.001	.001	3	4
STOMACH	C19orf81 →	+1.826	+1.693	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMP2K by Negative regulation of autophagosome assembly activity — SKIN

Explore this box plot interactively →