Positive regulation of miRNA transcription

Across TCGA cell cohorts, RNA activity of the Positive regulation of miRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN4, MREG, and OVOL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLDN4 grouped by Positive regulation of miRNA transcription-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CLDN4 →	+5.691	+0.249	<.001	.008	3	5
UPPER_AERODIGESTIVE_TRACT	MREG →	+0.591	+0.165	.006	.002	3	5
LUNG_NSCLC_LUAD	OVOL1 →	+1.904	+0.208	<.001	.001	3	4
LUNG_NSCLC_LUAD	RPS27L →	-1.118	-0.233	<.001	<.001	3	4
LUNG_NSCLC_LUAD	EID3 →	-1.841	-0.183	<.001	.007	3	4
URINARY_TRACT	CDH1 →	+6.042	+0.331	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLDN4 by Positive regulation of miRNA transcription activity — URINARY_TRACT

Explore this box plot interactively →