Regulation of miRNA transcription

Across TCGA patient cohorts, RNA activity of the Regulation of miRNA transcription pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRPK1_S311, LAMB1, and USP10_S365, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of miRNA transcription activity versus SRPK1_S311 in BRCA (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRPK1_S311 →	-0.632	-0.029	.001	.002	3	6
HNSC	LAMB1 →	+0.396	+0.054	.001	.003	3	6
BRCA	USP10_S365 →	-0.644	-0.032	.002	.003	3	6
BRCA	NID1 →	+0.355	+0.026	.002	.003	3	6
CCRCC	LAMA4 →	+0.533	+0.040	<.001	<.001	3	6
BRCA	CNPY4 →	+0.211	+0.018	.006	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902893 vs SRPK1_S311 — BRCA

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