Regulation of miRNA transcription

Across TCGA cell cohorts, RNA activity of the Regulation of miRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RB1, FUT10, and EDEM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RB1 grouped by Regulation of miRNA transcription-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RB1 →	-0.604	-0.141	.002	.009	3	4
URINARY_TRACT	FUT10 →	-0.885	-0.271	.001	<.001	2	5
LUNG_NSCLC_LUSC	EDEM2 →	+1.406	+0.353	.008	<.001	3	4
LUNG_NSCLC_LUAD	RPS27L →	-1.106	-0.209	.001	.001	3	4
BLOOD_Myeloma	ECH1 →	+1.113	+0.301	.007	.005	3	4
BLOOD_Leukemia	SUMF2 →	+1.085	+0.280	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RB1 by Regulation of miRNA transcription activity — PANCREAS

Explore this box plot interactively →