Regulation of response to oxidative stress

Across TCGA patient cohorts, RNA activity of the Regulation of response to oxidative stress pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNTB2_S222, U2SURP, and LMOD1_S85, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to oxidative stress activity versus SNTB2_S222 in BRCA (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNTB2_S222 →	+0.546	+0.024	.001	.006	2	7
BRCA	U2SURP →	-0.214	-0.038	.003	<.001	3	6
LSCC	LMOD1_S85 →	+0.698	+0.033	.001	.002	3	6
OV	EPB41L3 →	+0.530	+0.032	.002	.005	3	6
COAD	NNMT →	+0.470	+0.032	<.001	<.001	3	6
LSCC	PRKG1 →	+0.424	+0.056	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902882 vs SNTB2_S222 — BRCA

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