Regulation of response to oxidative stress

Across TCGA cell cohorts, RNA activity of the Regulation of response to oxidative stress pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3D, ACTN2, and EML6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to oxidative stress activity versus EIF3D in OVARY (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EIF3D →	-1.339	-0.234	.005	.005	2	7
LUNG_NSCLC_LUAD	ACTN2 →	-1.356	-0.216	.001	.004	3	6
BLOOD_Leukemia	EML6 →	-0.615	-0.194	.009	<.001	2	6
BLOOD_Leukemia	RPL35 →	-0.376	-0.132	.003	.005	3	5
BLOOD_Leukemia	G6PD →	-0.697	-0.229	<.001	.004	3	5
OVARY	RPL26 →	-0.890	-0.290	.003	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902882 vs EIF3D — OVARY

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