Regulation of amacrine cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of amacrine cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADNP, PLCG1, and PNN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amacrine cell differentiation activity versus ADNP in HNSC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ADNP →	+0.265	+0.100	.001	<.001	3	6
COAD	PLCG1 →	+0.236	+0.062	.001	<.001	3	6
CCRCC	PNN →	+0.163	+0.040	<.001	.003	3	6
LSCC	ADNP_S921 →	+0.433	+0.073	.002	.003	2	6
HNSC	CEP170B →	-0.350	-0.090	.001	.002	3	5
COAD	ITPRID2 →	-0.302	-0.067	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902869 vs ADNP — HNSC

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