Regulation of amacrine cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of amacrine cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA3G, KLF3, and ABHD17C, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amacrine cell differentiation activity versus SEMA3G in LSCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEMA3G →	-0.486	-0.720	.005	.007	3	3
LSCC	KLF3 →	+0.725	+0.808	<.001	.004	3	3
LSCC	ABHD17C →	+0.933	+0.814	.001	.002	3	3
LSCC	TDRD10 →	-0.770	-0.891	.004	<.001	3	3
BRCA	HSD17B14 →	-1.430	-0.299	<.001	.008	3	3
PDAC	MPP1 →	-0.374	-0.246	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902869 vs SEMA3G — LSCC

Explore this scatter interactively →