Regulation of amacrine cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of amacrine cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KYAT1, PPP3CA, and DRC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KYAT1 grouped by Regulation of amacrine cell differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KYAT1 →	+0.729	+1.235	.005	.003	3	4
BLOOD_Lymphoma	PPP3CA →	+1.494	+1.743	.003	.007	3	4
OESOPHAGUS	DRC3 →	+1.011	+1.319	.003	.001	3	4
LUNG_NSCLC_LUSC	FBXO42 →	+0.768	+1.439	.003	<.001	3	4
LARGE_INTESTINE	LIN54 →	+0.800	+0.822	<.001	.002	3	4
LARGE_INTESTINE	KIFAP3 →	+1.192	+1.443	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KYAT1 by Regulation of amacrine cell differentiation activity — SOFT_TISSUE

Explore this box plot interactively →