Regulation of amacrine cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of amacrine cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLX1, DLX2, and DENND1C, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amacrine cell differentiation activity versus DLX1 in LIVER (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DLX1 →	+3.411	+1.412	<.001	<.001	3	20
LUNG_SCLC	DLX2 →	+3.241	+1.433	<.001	<.001	3	18
URINARY_TRACT	DENND1C →	-2.746	-0.969	<.001	<.001	3	10
OVARY	METAP1D →	+0.855	+0.997	<.001	<.001	3	10
URINARY_TRACT	CRB3 →	-3.699	-1.047	<.001	.001	3	10
URINARY_TRACT	MUC20 →	-3.382	-0.853	.003	.009	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902869 vs DLX1 — LIVER

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