Regulation of non-motile cilium assembly

Across TCGA patient cohorts, RNA activity of the Regulation of non-motile cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPJ, CEP135, and CCDC18, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of non-motile cilium assembly activity versus CENPJ in DLBC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	CENPJ →	+0.907	+0.053	<.001	<.001	3	28
DLBC	CEP135 →	+1.040	+0.051	<.001	<.001	3	26
DLBC	CCDC18 →	+1.054	+0.064	<.001	<.001	2	25
DLBC	CEP85 →	+1.192	+0.064	.004	<.001	3	24
MESO	PLK4 →	+1.195	+0.043	<.001	<.001	3	24
DLBC	MMS22L →	+0.834	+0.088	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902855 vs CENPJ — DLBC

Explore this scatter interactively →