Regulation of non-motile cilium assembly

Across TCGA cell cohorts, RNA activity of the Regulation of non-motile cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDR39U1, DNAJC17, and GTPBP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDR39U1 grouped by Regulation of non-motile cilium assembly-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SDR39U1 →	-0.399	-0.659	.002	.001	3	4
SOFT_TISSUE	DNAJC17 →	-0.587	-1.673	<.001	<.001	3	4
LUNG_NSCLC_LUAD	GTPBP3 →	-0.670	-0.814	.001	.001	3	4
BLOOD_Leukemia	EAF1 →	-0.754	-1.462	.002	.001	3	4
LIVER	ARNTL2 →	+1.091	+1.457	.004	.005	3	4
LUNG_SCLC	NUDT5 →	+0.606	+0.926	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDR39U1 by Regulation of non-motile cilium assembly activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →