Microtubule cytoskeleton organization involved in mitosis

Across TCGA patient cohorts, RNA activity of the Microtubule cytoskeleton organization involved in mitosis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR4, GPR108, and GNG5P2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule cytoskeleton organization involved in mitosis activity versus PRR4 in COAD (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PRR4 →	-1.097	-0.219	.002	.005	3	1
COAD	GPR108 →	-0.256	-0.273	.004	.001	3	1
COAD	GNG5P2 →	+0.873	+0.273	.005	.001	3	1
COAD	UGCG →	+0.623	+0.266	.002	.001	3	1
COAD	RPUSD3 →	-0.337	-0.219	.002	.005	3	1
COAD	RETNLB →	+1.559	+0.219	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902850 vs PRR4 — COAD

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