Microtubule cytoskeleton organization involved in mitosis

Across TCGA patient cohorts, RNA activity of the Microtubule cytoskeleton organization involved in mitosis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CFAP20, UBE2V1, and ZZEF1_S1537, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule cytoskeleton organization involved in mitosis activity versus CFAP20 in COAD (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CFAP20 →	-0.473	-0.246	<.001	<.001	3	1
COAD	UBE2V1 →	-0.592	-0.246	.006	<.001	2	1
COAD	ZZEF1_S1537 →	+0.793	+0.273	.005	.001	2	1
COAD	ZZEF1_S1540 →	+0.793	+0.273	.005	.001	2	1
COAD	CHD2 →	-0.450	-0.264	<.001	<.001	2	1
COAD	CLCA1 →	+1.123	+0.270	<.001	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902850 vs CFAP20 — COAD

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