Positive regulation of cell cycle G1/S phase transition

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell cycle G1/S phase transition pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF4G1_S1092, UFD1_S247, and SMG7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle G1/S phase transition activity versus EIF4G1_S1092 in BRCA (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EIF4G1_S1092 →	+0.775	+0.167	<.001	<.001	3	5
OV	UFD1_S247 →	+0.928	+0.489	<.001	.002	2	6
BRCA	SMG7 →	+0.213	+0.135	<.001	<.001	3	4
OV	SOD3_S195 →	-2.891	-0.716	<.001	<.001	2	5
OV	SVIL_S547 →	-1.162	-0.513	<.001	.003	3	4
GBM	C1orf35 →	+0.306	+0.243	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902808 vs EIF4G1_S1092 — BRCA

Explore this scatter interactively →