Positive regulation of cell cycle G1/S phase transition

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell cycle G1/S phase transition pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DTX4, CAP2, and ZNF585A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DTX4 grouped by Positive regulation of cell cycle G1/S phase transition-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DTX4 →	+4.045	+0.283	.001	.005	3	6
PANCREAS	CAP2 →	-1.618	-0.315	.007	.005	3	5
OVARY	ZNF585A →	-1.998	-0.157	.002	.005	3	5
LIVER	RPS23 →	-0.821	-0.306	<.001	.007	3	5
PANCREAS	CHST7 →	-1.546	-0.283	.003	.003	3	4
BLOOD_Myeloma	KIAA1217 →	-2.856	-0.267	.009	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DTX4 by Positive regulation of cell cycle G1/S phase transition activity — URINARY_TRACT

Explore this box plot interactively →