Negative regulation of cell cycle G1/S phase transition

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell cycle G1/S phase transition pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHAF1A, FANCB, and CENPM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell cycle G1/S phase transition activity versus CHAF1A in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CHAF1A →	+0.613	+1.109	<.001	<.001	3	6
HNSC	FANCB →	+0.792	+0.672	.001	.001	3	6
GBM	CENPM →	+1.030	+1.026	<.001	<.001	3	5
GBM	NEK2 →	+0.969	+1.272	<.001	<.001	3	5
GBM	CENPF →	+1.182	+0.855	<.001	<.001	3	5
BRCA	PKMYT1 →	+0.668	+0.628	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902807 vs CHAF1A — GBM

Explore this scatter interactively →