Negative regulation of cell cycle G1/S phase transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell cycle G1/S phase transition pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUPT5H, PAF1, and GPLD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUPT5H grouped by Negative regulation of cell cycle G1/S phase transition-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SUPT5H →	+1.188	+0.260	.002	.001	3	4
STOMACH	PAF1 →	+1.041	+0.318	.002	.001	3	4
URINARY_TRACT	GPLD1 →	-2.413	-0.298	.008	.008	3	4
URINARY_TRACT	PLA2G6 →	-1.832	-0.267	.002	.003	3	4
OVARY	SESN1 →	-1.291	-0.214	<.001	.002	3	4
BONE	ATF7 →	-0.967	-0.341	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUPT5H by Negative regulation of cell cycle G1/S phase transition activity — STOMACH

Explore this box plot interactively →