Negative regulation of cell cycle G1/S phase transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell cycle G1/S phase transition pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UQCC3, ARL2, and PCBP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell cycle G1/S phase transition activity versus UQCC3 in CNS (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UQCC3 →	-0.663	-0.204	<.001	.002	3	5
SKIN	ARL2 →	-0.773	-0.280	<.001	<.001	3	4
LIVER	PCBP2 →	-0.515	-0.292	.009	.009	3	4
CNS	FADS3 →	+1.126	+0.224	.003	.001	3	4
KIDNEY	CCDC138 →	-0.832	-0.325	.003	<.001	3	4
PANCREAS	TWNK →	-0.826	-0.270	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902807 vs UQCC3 — CNS

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