Regulation of cell cycle G1/S phase transition

Across TCGA patient cohorts, RNA activity of the Regulation of cell cycle G1/S phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPO, MIR155HG, and DICER1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell cycle G1/S phase transition activity versus TSPO in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TSPO →	+0.721	+0.254	.003	<.001	2	2
BRCA	MIR155HG →	+1.373	+0.298	.004	.007	3	1
COAD	DICER1 →	-0.812	-0.474	<.001	.007	3	1
COAD	GNB3 →	-0.483	-0.605	.001	.009	3	1
COAD	EPCAM →	+0.563	+0.555	.009	.007	3	1
COAD	MPST →	+0.562	+0.535	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902806 vs TSPO — BRCA

Explore this scatter interactively →