Regulation of synaptic vesicle transport

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic vesicle transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2, MAP2_S1155, and MAP2_S1790, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle transport activity versus MAP2 in LSCC (Pearson r = 0.79).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP2 →	+1.062	+0.934	<.001	<.001	3	8
LSCC	MAP2_S1155 →	+1.892	+1.134	<.001	<.001	3	6
LSCC	MAP2_S1790 →	+1.427	+0.761	<.001	<.001	3	6
LSCC	MAP2_T1649 →	+1.516	+0.937	<.001	<.001	3	6
BRCA	MAP2_S1480 →	+1.966	+0.925	<.001	<.001	3	6
LUAD	MAP2_S136 →	+1.255	+0.800	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902803 vs MAP2 — LSCC

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