Regulation of synaptic vesicle transport

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle transport pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NELFA, DPP3, and PKM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle transport activity versus NELFA in OVARY (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NELFA →	-1.494	-0.189	.007	<.001	3	3
OVARY	DPP3 →	-1.257	-0.180	.003	<.001	3	3
OVARY	PKM →	-1.269	-0.114	.005	.003	3	3
OVARY	DNM1L →	-1.216	-0.184	.002	<.001	3	3
OVARY	ARFGAP1 →	-0.752	-0.144	.009	.005	3	3
OVARY	BLVRA →	-1.907	-0.151	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902803 vs NELFA — OVARY

Explore this scatter interactively →