Late endosome to lysosome transport

Across TCGA patient cohorts, RNA activity of the Late endosome to lysosome transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS19, RRBP1_T275, and RPS5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to lysosome transport activity versus RPS19 in GBM (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPS19 →	-0.174	-0.036	<.001	.002	3	7
COAD	RRBP1_T275 →	-0.574	-0.025	.003	<.001	2	7
PDAC	RPS5 →	-0.158	-0.033	.004	.008	2	7
OV	API5_S464 →	-0.568	-0.038	.004	<.001	3	5
LSCC	MORC2_S725 →	-0.749	-0.049	.002	.002	2	6
COAD	YME1L1 →	-0.224	-0.017	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902774 vs RPS19 — GBM

Explore this scatter interactively →