Late endosome to lysosome transport

Across TCGA patient cohorts, RNA activity of the Late endosome to lysosome transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRBA_S2496, KMT2B_S821, and MAP2K4_S394, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to lysosome transport activity versus LRBA_S2496 in HNSC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LRBA_S2496 →	+0.509	+0.139	<.001	<.001	3	4
PDAC	KMT2B_S821 →	-0.812	-0.202	<.001	<.001	3	4
OV	MAP2K4_S394 →	+1.990	+0.570	<.001	<.001	3	4
GBM	SPTY2D1 →	-0.747	-0.177	<.001	<.001	3	3
OV	COBLL1_S947 →	+0.962	+0.264	<.001	<.001	3	3
OV	LARP7_S300 →	-0.948	-0.218	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902774 vs LRBA_S2496 — HNSC

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