Late endosome to lysosome transport

Across TCGA cell cohorts, RNA activity of the Late endosome to lysosome transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BECN1, MLX, and STK36, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to lysosome transport activity versus BECN1 in LARGE_INTESTINE (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BECN1 →	+0.400	+0.695	.005	.007	3	6
LARGE_INTESTINE	MLX →	+0.594	+1.029	.003	.004	3	5
LUNG_NSCLC_LUSC	STK36 →	+1.243	+1.412	<.001	.001	3	4
PANCREAS	RAPGEF1 →	+0.695	+1.155	.008	<.001	3	4
PANCREAS	SLC25A38 →	+0.984	+1.245	.004	.003	3	4
PANCREAS	UBP1 →	+0.711	+1.197	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902774 vs BECN1 — LARGE_INTESTINE

Explore this scatter interactively →