Positive regulation of cell cycle G2/M phase transition

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF11, KIF18A, and FANCI, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle G2/M phase transition activity versus KIF11 in LUAD (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIF11 →	+0.732	+0.184	<.001	<.001	3	8
BRCA	KIF18A →	+0.717	+0.168	<.001	<.001	3	8
LSCC	FANCI →	+0.716	+0.154	.001	.003	3	8
UCEC	BUB1B →	+0.885	+0.205	.002	<.001	3	8
BRCA	BLM →	+0.757	+0.224	<.001	<.001	3	8
BRCA	FBXO5 →	+0.641	+0.174	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902751 vs KIF11 — LUAD

Explore this scatter interactively →