Positive regulation of cell cycle G2/M phase transition

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMN1, BLID, and FHOD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FMN1 grouped by Positive regulation of cell cycle G2/M phase transition-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FMN1 →	+1.498	+0.222	.001	.006	3	7
LUNG_NSCLC_LUSC	BLID →	+0.320	+0.153	.005	.004	3	5
BREAST	FHOD1 →	+1.225	+0.132	<.001	.001	2	6
STOMACH	SDSL →	+2.513	+0.121	<.001	.009	3	5
BREAST	OSBPL7 →	+1.453	+0.140	.001	<.001	3	5
LIVER	VPS37B →	+1.373	+0.279	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FMN1 by Positive regulation of cell cycle G2/M phase transition activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →