Positive regulation of cell cycle G2/M phase transition

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNOT8, SLC35C1, and SLC35B4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle G2/M phase transition activity versus CNOT8 in OVARY (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CNOT8 →	+0.634	+0.117	.001	.002	3	5
LUNG_NSCLC_LUSC	SLC35C1 →	-0.972	-0.120	.006	.001	3	4
LUNG_NSCLC_LUSC	SLC35B4 →	-0.864	-0.114	.004	.002	3	4
KIDNEY	RNFT1 →	-1.409	-0.160	.004	.009	3	4
KIDNEY	BTN3A1 →	+1.374	+0.124	.008	.007	3	4
OESOPHAGUS	NUDT4 →	-1.165	-0.201	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902751 vs CNOT8 — OVARY

Explore this scatter interactively →