Negative regulation of cell cycle G2/M phase transition

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP152, ORC2, and FIGNL1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell cycle G2/M phase transition activity versus CEP152 in SCLC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CEP152 →	+1.768	+0.083	<.001	<.001	3	34
UVM	ORC2 →	+1.044	+0.041	<.001	<.001	3	34
DLBC	FIGNL1 →	+1.074	+0.063	<.001	<.001	3	34
UVM	KHDC4 →	+1.176	+0.045	<.001	<.001	3	34
UVM	WDR36 →	+1.343	+0.037	<.001	<.001	3	34
UVM	CEP350 →	+1.197	+0.041	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902750 vs CEP152 — SCLC

Explore this scatter interactively →