Negative regulation of cell cycle G2/M phase transition

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGH, GINS1, and SGO1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell cycle G2/M phase transition activity versus GGH in OV (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GGH →	+0.842	+0.660	.004	.001	3	6
BRCA	GINS1 →	+1.138	+1.018	<.001	<.001	3	5
BRCA	SGO1 →	+1.049	+0.964	<.001	<.001	3	5
BRCA	CCNB1 →	+0.739	+0.721	<.001	<.001	3	5
BRCA	CDCA5 →	+1.400	+1.030	<.001	<.001	3	5
OV	CDC25C →	+0.828	+0.573	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902750 vs GGH — OV

Explore this scatter interactively →