Negative regulation of cell cycle G2/M phase transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHFR2, CA9, and AMN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHFR2 grouped by Negative regulation of cell cycle G2/M phase transition-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DHFR2 →	+0.992	+0.278	.007	.008	3	4
LARGE_INTESTINE	CA9 →	+2.780	+0.134	.001	.004	3	4
LARGE_INTESTINE	AMN →	+2.034	+0.153	.002	.002	3	4
LUNG_SCLC	OXCT2 →	+1.772	+0.170	.009	.005	3	4
KIDNEY	MOCOS →	+0.870	+0.341	.002	.001	2	5
LIVER	PARN →	-0.611	-0.222	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHFR2 by Negative regulation of cell cycle G2/M phase transition activity — BONE

Explore this box plot interactively →