Regulation of cell cycle G2/M phase transition

Across TCGA patient cohorts, RNA activity of the Regulation of cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC25A, ARHGAP11A, and DEPDC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell cycle G2/M phase transition activity versus CDC25A in OV (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDC25A →	+0.986	+0.259	<.001	<.001	3	6
BRCA	ARHGAP11A →	+0.790	+0.467	<.001	<.001	3	6
OV	DEPDC1 →	+0.972	+0.208	<.001	.002	3	6
BRCA	CDC45 →	+1.063	+0.441	<.001	<.001	3	6
BRCA	MCM4 →	+0.988	+0.712	<.001	<.001	3	5
BRCA	KIF20A →	+0.862	+0.578	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902749 vs CDC25A — OV

Explore this scatter interactively →