Regulation of cell cycle G2/M phase transition

Across TCGA cell cohorts, RNA activity of the Regulation of cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF311, DDAH2, and IFI44L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF311 grouped by Regulation of cell cycle G2/M phase transition-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF311 →	+0.771	+0.125	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	DDAH2 →	+1.350	+0.176	.005	.007	3	4
URINARY_TRACT	IFI44L →	+1.251	+0.276	.004	.003	3	4
PANCREAS	PPM1H →	-0.998	-0.108	.001	.003	3	4
PANCREAS	PSRC1 →	-0.985	-0.158	<.001	<.001	3	4
PANCREAS	AURKB →	-1.015	-0.132	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF311 by Regulation of cell cycle G2/M phase transition activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →