Regulation of cell cycle G2/M phase transition

Across TCGA cell cohorts, RNA activity of the Regulation of cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN4, RBM4, and PLK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell cycle G2/M phase transition activity versus PTPN4 in BLOOD_Myeloma (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PTPN4 →	-1.225	-0.318	.001	.005	3	4
OESOPHAGUS	RBM4 →	-0.667	-0.143	.001	.002	3	3
STOMACH	PLK2 →	-2.469	-0.157	.003	.003	3	3
STOMACH	INSR →	+1.002	+0.178	.005	.002	3	3
KIDNEY	CPAMD8 →	+0.430	+0.263	<.001	.005	3	3
UPPER_AERODIGESTIVE_TRACT	MTUS1 →	-1.359	-0.202	.009	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902749 vs PTPN4 — BLOOD_Myeloma

Explore this scatter interactively →