Negative regulation of lens fiber cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of lens fiber cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRY1, FOXE3, and SPRED1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPRY1 grouped by Negative regulation of lens fiber cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SPRY1 →	-0.363	-1.209	<.001	<.001	3	12
CNS	FOXE3 →	-0.255	-1.336	<.001	<.001	3	7
BLOOD_Leukemia	SPRED1 →	-0.238	-0.929	.002	.004	3	6
KIDNEY	SPRED2 →	-0.288	-1.502	.003	.002	3	5
OVARY	SPRY2 →	-0.235	-1.072	<.001	<.001	3	4
PANCREAS	AKR1B10 →	-0.164	-1.557	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPRY1 by Negative regulation of lens fiber cell differentiation activity — BREAST

Explore this box plot interactively →