Negative regulation of lens fiber cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of lens fiber cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM32A, RPL35, and HHLA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM32A grouped by Negative regulation of lens fiber cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM32A →	-0.512	-0.239	.001	.001	3	4
CNS	RPL35 →	+0.363	+0.110	.005	.001	3	4
BLOOD_Myeloma	HHLA2 →	+0.274	+0.196	<.001	.002	3	3
BLOOD_Myeloma	ARID3B →	-0.409	-0.196	<.001	.002	3	3
BREAST	LUC7L →	+0.105	+0.569	.007	.002	3	3
LARGE_INTESTINE	AHCTF1 →	+0.360	+0.153	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM32A by Negative regulation of lens fiber cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →