Negative regulation of lens fiber cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of lens fiber cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRED2, SPRY2, and SPRY1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lens fiber cell differentiation activity versus SPRED2 in BLOOD_Myeloma (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SPRED2 →	+2.437	+1.592	<.001	<.001	3	18
SOFT_TISSUE	SPRY2 →	+3.320	+0.227	<.001	<.001	3	16
STOMACH	SPRY1 →	+2.661	+0.189	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	ETV5 →	+2.269	+1.153	<.001	<.001	3	15
BLOOD_Myeloma	SPRED1 →	+1.667	+0.992	<.001	.002	3	15
OVARY	DUSP6 →	+2.790	+0.623	<.001	.005	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902747 vs SPRED2 — BLOOD_Myeloma

Explore this scatter interactively →