Regulation of lens fiber cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of lens fiber cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPU, SEPTIN14P12, and HJURP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lens fiber cell differentiation activity versus CENPU in COAD (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CENPU →	-0.528	-0.613	.001	<.001	3	5
LSCC	SEPTIN14P12 →	-0.800	-0.732	<.001	.001	3	5
LSCC	HJURP →	-0.862	-0.799	<.001	<.001	3	5
HNSC	KIF2C →	-0.519	-0.629	.006	<.001	3	5
HNSC	MCM10 →	-0.664	-0.653	.001	.002	3	5
LSCC	CDC45 →	-0.500	-0.589	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902746 vs CENPU — COAD

Explore this scatter interactively →