Regulation of lens fiber cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of lens fiber cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WWC1, LYN, and RTN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WWC1 grouped by Regulation of lens fiber cell differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	WWC1 →	-1.339	-0.688	.006	.009	3	4
CNS	LYN →	-1.204	-0.792	<.001	.002	3	4
BONE	RTN4 →	-1.589	-1.915	.001	<.001	3	4
SKIN	FAM13B →	-0.592	-1.008	.007	.001	3	4
CNS	PCSK6 →	-1.800	-1.237	<.001	<.001	3	3
OVARY	HSPB1 →	-1.374	-0.869	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WWC1 by Regulation of lens fiber cell differentiation activity — CNS

Explore this box plot interactively →