Regulation of lens fiber cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of lens fiber cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYS1-DBNDD2, FAM32A, and WNT10A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYS1-DBNDD2 grouped by Regulation of lens fiber cell differentiation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SYS1-DBNDD2 →	+0.202	+0.190	.002	.003	3	4
LARGE_INTESTINE	FAM32A →	-0.474	-0.240	<.001	<.001	3	4
BLOOD_Myeloma	WNT10A →	-0.500	-0.190	.007	.003	3	3
BLOOD_Myeloma	ARID3B →	-0.409	-0.190	<.001	.003	3	3
LIVER	SIRPB2 →	-0.165	-0.140	.002	.005	3	3
SKIN	AXIN1 →	-0.213	-0.169	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYS1-DBNDD2 by Regulation of lens fiber cell differentiation activity — BLOOD_Myeloma

Explore this box plot interactively →