Regulation of lens fiber cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of lens fiber cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRY2, SPRED1, and SPRED2, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lens fiber cell differentiation activity versus SPRY2 in BREAST (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SPRY2 →	+2.371	+0.740	<.001	.003	3	15
BLOOD_Myeloma	SPRED1 →	+1.540	+0.983	.001	.003	2	16
BLOOD_Myeloma	SPRED2 →	+2.375	+1.616	<.001	<.001	3	15
STOMACH	SPRY1 →	+2.683	+0.192	<.001	<.001	2	15
BREAST	SPRY4 →	+2.770	+0.895	<.001	<.001	3	14
BLOOD_Myeloma	ETV5 →	+2.610	+1.174	<.001	.002	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902746 vs SPRY2 — BREAST

Explore this scatter interactively →