Positive regulation of lamellipodium organization

Across TCGA patient cohorts, RNA activity of the Positive regulation of lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSBPL2, COL27A1, and ACSL3-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lamellipodium organization activity versus OSBPL2 in HNSC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OSBPL2 →	+0.251	+0.067	.002	<.001	2	4
HNSC	COL27A1 →	+0.764	+0.104	.001	<.001	3	3
GBM	ACSL3-AS1 →	+0.687	+0.106	<.001	<.001	3	3
LUAD	DZIP1L →	+0.570	+0.099	.002	<.001	3	3
LUAD	ARFGAP3 →	+0.247	+0.086	.007	.001	3	3
BRCA	NLE1 →	-0.518	-0.181	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902745 vs OSBPL2 — HNSC

Explore this scatter interactively →