Positive regulation of lamellipodium organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of lamellipodium organization pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC1, ACTR2, and RAPGEF1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAC1 grouped by Positive regulation of lamellipodium organization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RAC1 →	-0.553	-0.391	<.001	.001	3	14
STOMACH	ACTR2 →	-0.425	-0.659	<.001	.002	3	12
STOMACH	RAPGEF1 →	-0.396	-0.608	.001	.002	3	11
STOMACH	ACTR3 →	-0.447	-0.671	.001	.001	3	8
URINARY_TRACT	TLN1 →	-0.506	-0.455	<.001	<.001	3	8
LUNG_NSCLC_LUAD	YAP1 →	-0.284	-0.429	.004	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAC1 by Positive regulation of lamellipodium organization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →