Positive regulation of lamellipodium organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D2, RCOR2, and ZBTB40, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D2 grouped by Positive regulation of lamellipodium organization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TBC1D2 →	+1.826	+0.655	<.001	<.001	3	5
URINARY_TRACT	RCOR2 →	-1.102	-0.447	.005	.005	2	6
OVARY	ZBTB40 →	-0.828	-0.459	<.001	<.001	3	5
OVARY	COQ8A →	-1.098	-0.637	<.001	.001	3	4
CNS	GRK3 →	-0.752	-0.637	.009	.004	3	4
CNS	NHEJ1 →	-0.490	-0.496	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D2 by Positive regulation of lamellipodium organization activity — STOMACH

Explore this box plot interactively →