Positive regulation of lamellipodium organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of lamellipodium organization pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX19, SPATA22, and RARS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBX19 grouped by Positive regulation of lamellipodium organization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBX19 →	+0.438	+0.087	.002	.002	3	5
BREAST	SPATA22 →	+0.165	+0.091	.002	<.001	3	5
CNS	RARS2 →	+0.358	+0.086	<.001	.003	3	4
STOMACH	CELA3B →	+0.411	+0.146	.004	.002	3	4
LUNG_NSCLC_LUAD	SEC1P →	+0.146	+0.070	.004	.004	3	4
LUNG_SCLC	MRPL51 →	-0.272	-0.124	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBX19 by Positive regulation of lamellipodium organization activity — LARGE_INTESTINE

Explore this box plot interactively →