Positive regulation of lamellipodium organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO1C, ARHGAP22, and STARD8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lamellipodium organization activity versus CORO1C in OVARY (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CORO1C →	+1.118	+0.435	.001	<.001	3	8
OVARY	ARHGAP22 →	+1.959	+0.360	.003	.002	3	6
BLOOD_Leukemia	STARD8 →	+1.704	+0.182	.001	.006	3	6
PANCREAS	TWF2 →	+0.891	+0.380	<.001	<.001	3	6
PANCREAS	SH2B3 →	+1.155	+0.327	<.001	<.001	3	6
LUNG_NSCLC_LUSC	EMP3 →	+4.922	+0.602	.008	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902745 vs CORO1C — OVARY

Explore this scatter interactively →