Negative regulation of lamellipodium organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDH1, CENPJ, and FABP6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IDH1 grouped by Negative regulation of lamellipodium organization-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IDH1 →	+2.347	+2.108	.002	<.001	3	4
PANCREAS	CENPJ →	+0.642	+0.502	.002	.008	3	3
KIDNEY	FABP6 →	-3.602	-1.534	.002	<.001	3	3
KIDNEY	SLC4A8 →	-1.505	-1.278	.002	.006	3	3
BONE	RAPGEFL1 →	+1.557	+1.688	.009	.004	3	3
SOFT_TISSUE	ZNF30 →	+0.907	+0.947	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IDH1 by Negative regulation of lamellipodium organization activity — URINARY_TRACT

Explore this box plot interactively →