Negative regulation of lamellipodium organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLIT2, PLXNB3, and LYPD1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lamellipodium organization activity versus SLIT2 in URINARY_TRACT (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLIT2 →	-2.164	-0.153	.002	<.001	3	9
LIVER	PLXNB3 →	-2.144	-0.151	<.001	.003	3	8
LIVER	LYPD1 →	-3.063	-0.189	.005	.001	3	6
LIVER	TMEM154 →	-1.673	-0.151	.006	.008	2	7
LARGE_INTESTINE	MID2 →	-0.703	-0.079	.002	<.001	3	6
LIVER	FLT3LG →	-1.400	-0.188	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902744 vs SLIT2 — URINARY_TRACT

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