Negative regulation of lamellipodium organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF31, XPNPEP3, and ABL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lamellipodium organization activity versus PRPF31 in BLOOD_Lymphoma (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRPF31 →	-0.670	-0.141	.006	.001	3	4
CNS	XPNPEP3 →	-1.015	-0.186	.001	<.001	3	3
CNS	ABL1 →	-0.785	-0.207	.001	.002	3	3
OESOPHAGUS	PTPN11 →	-0.578	-0.231	.003	.001	3	3
OESOPHAGUS	DARS2 →	-0.629	-0.198	.009	.005	3	3
OESOPHAGUS	TRIM32 →	-0.723	-0.256	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902744 vs PRPF31 — BLOOD_Lymphoma

Explore this scatter interactively →